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Additionally, our proposal could explain most elastin peptides biological effects and their physiopathological consequences.
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Further, we feel that GM3/LacCer conversion could be a fundamental event of elastin peptides biology as it could explain most aspects of their biological activities.
The high insolubility of elastin has limited its use to researchers, while soluble derivatives of elastin including elastin peptides, digested elastins, and tropoelastin have much broader applications.
Soluble elastin as well as elastin peptides are potent inhibitors of the metastatic process in experimental tumor models.
This important finding may help for peptide design and is in line with recent studies on bioactive elastin peptides.
On the other hand, elastin peptides can also be used to design targeted therapies exploiting the unique physicochemical nature of this matrix protein.
The biological activity of elastin peptides is regulated by their binding to the elastin receptor complex.
Soluble elastin peptides were further obtained from insoluble elastin by organo-alkaline hydrolysis.
In fibroblasts, elastin peptides induce ERK 1/2 activation through the elastin receptor complex [9].
Elastin peptides were prepared as described previously [7].
This protein can be degraded in elastin peptides.
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