Significantly less replicative capacity was consistently observed in cultures in which hStn1 knockdown was most efficient (shStn1-2), indicathat that it is tightly correlated with hStn1 levels and function (Fig. 1C).
These experiments revealed a decay rate for phloretin of 1.4 × 10−2 min−1 and a τ/2 of 51 min (Fig. 1D) indicating most efficient adduct formation under these conditions.
Finally, the pol2 18 profile most closely resembled the wild-type profile, indicating the most efficient scaling of its temporal replication program with S phase duration.
Although we designed certain amiRNAs (i.e., pTP-mi5 and Pol-mi4) to contain the same seed sequences as their successful siRNA relatives used in our previous study (Kneidinger et al., 2012), these amiRNAs did not necessarily represent the most efficient amiRNAs (see Pol-mi4), indicating that it was not always feasible to automatically convert an effective siRNA into a potent amiRNA.
Although downregulation of Bim or Bid alone already resulted in reduced TRAIL plus doxorubicin-induced DEVDase activity, combined knockdown of Bid and Bim was most efficient in preventing caspase activation, indicating that both BH3-only proteins are involved in mediating synergistic induction of cell death by TRAIL and doxorubicin.
The results indicate the most efficient design methodology.
In the case of the betweenness centrality, it may indicate the most efficient authors to act as bridges to carry information among different authors or communities.
A reaction mixture containing 1.005 mmol L−1 of ferrioxalate and 17.5 mmol L−1 of hydrogen peroxide, added at the initial reaction period, pH of 6.1 and 60 min of degradation indicated the most efficient degradation, promoting 95% of MEF removal.
The results indicate that the most efficient HRSC configuration is based on a gas turbine combined cycle with supplementary firing in two HRSG sections.
The results indicate that the most efficient input parameters are the tamper weight, the height of tamping and the grid spacing.
