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For persons enrolled for less than 1 year (i.e., January 1 , 2007 December 31 , 2007 the most efficient definition of follow-up loss was 47 days.
For persons enrolled for at least 1 year but less than 2 years (i.e., January 1 , 2006 December 31 , 2006 the most efficient definition of follow-up loss was 60 days.
Because the chances of such misclassification may be reduced among "older" enrollment cohorts, the performance of the "most efficient" definition of loss to follow-up was generally better in those groups.
For persons enrolled for at least 2 years but less than 3 years (i.e., January 1 , 2005 December 31 , 2005, the most efficient definition of follow-up loss was 63 days.
When we performed analyses of separate enrollment cohorts, the most efficient definition of loss to follow-up appeared to shorten as duration of time in the program decreased (Table 2).
For persons enrolled for 3 years or longer (i.e., those who started ART prior to December 31 , 2004, the most efficient definition of follow-up loss was 70 days.
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The most efficient definitions using alternative cutoff days were: June 30, 2007 (62 days); September 30, 2007 (60 days); March 31 , 2008(62 days); and June 30 , 2008 59 days).
Our results showed that there are considerable gains in efficiency by reusing controls across time periods, and that our proposed control definition (i) is most efficient.
The second idea, arguing from the standpoint of pure engineering, insists that bridges making the most efficient possible use of materials are by definition beautiful.
Our proposed logistic regression approach which reuses controls according to definition (i) was the most efficient.
But uncertainty in the definition of restoration objectives, failure to identify most efficient practices and, particularly, socio-economic and cultural constrains may compromise future actions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com