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However, the single most significant impediment associated with this approach is the identification of the targets of the most efficacious small molecules.
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Despite reports of successful treatment of refractory Takayasu arteritis, polyarteritis nodosa, and Kawasaki disease, rituximab appears to be, among vasculitic syndromes, most efficacious in the treatment of small vessel vasculitides [ 29].
Firstly, evidence showed that the most efficacious analgesic intervention was to administer a small intravenous dose of lidocaine (lignocaine) with venous occlusion before the propofol injection; with lignocaine 40 mg, the best documented regimen, the number needed to treat to prevent any pain compared with placebo was 1.8 (95% confidence interval 1.5 to 2.2).
Despite the not infrequent occurrence of small population sizes where drift would be expected to be most efficacious, random genetic drift was considered an irrelevant evolutionary force in ecological genetics because natural selection was viewed as being particularly strong during periods of population decline.
We conclude that the most efficacious single dose of Q-Gel is 200 mg, and higher absorption is obtained using multiple smaller capsules.
Simvastatin efficacy studies were reviewed to define dietary contexts within which simvastatin is most efficacious.
Death was Hartley's most efficacious muse.
Jack Kemp lauded his former aide: "It will be proven the most efficacious of all the reforms".
Feinberg was by turns gentle and hostile, confiding and withholding, depending on what seemed most efficacious.
They will not be cured by our most efficacious drugs or slain with our sharpest swords.
In fact, methadone is one of the most, if not the most, efficacious of all the opioid analgesics for the treatment of human pain.
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