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In summary, the use of heparin once haemostasis has been achieved is the most efficacious option for trauma patients.
Obviously, this is a conservative assumption in the sense that it leads to an underestimation of the benefits associated to the most efficacious option.
A common topic of discussion was how large a contribution to patient care decisions should be made by patient needs and wants, particularly when the scientific evidence is reasonably clear about the most efficacious option.
Given the caveats of all observational studies, our data suggests that if clozapine monotherapy is ineffective, that augmentation with sodium valproate is the most efficacious option, followed by augmentation with amisulpride, lithium, quetiapine, and then lamotrigine.
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The future of personalized oncological therapy will likely rely on evidence-based medicine to integrate all of the available evidence to delineate the most efficacious treatment option for the patient.
Metformin has been chosen for the comparison group, for the following reasons: 1) the drug was shown to be one of the most efficacious therapeutic options available [ 23, 24]; 2) the clinical experience with the drug is extensive; and 3) it is a component of the comparison group vildagliptin-metformin combination.
A multi-target vaccine, combining different single-target vaccines acting on different biological functions and life stages of the parasite, e.g. susceptibility to larva migration, reproduction and life span, would prove the most effective option, especially if none of the single-target vaccines are highly efficacious, and would prove more robust against antigenic drift [34].
Transplant physicians are frequently faced with the difficult choice of selecting the most appropriate and efficacious option for oral antifungal prophylaxis in alloHCT recipients.
Insulin therapy remains the most efficacious glucose-lowering treatment option for type 2 diabetes (2) when lifestyle modifications and metformin fail to achieve recommended glycemic targets (3, 4).
PDE5 inhibitors are a safe and efficacious option for most elderly patients, and now represent first-line therapy also for their socio-economic impact (Anastasiadis et al 2002).
Data are needed to determine the most efficacious and safe non-surgical treatment options for patients with LSS.
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