12 13 However two of the most potent weight-inducing antipsychotics, clozapine and olanzapine, are also two of the most efficacious antipsychotic compounds, and especially clozapine is often used to treat patients resistant to other antipsychotics.
Cisplatin is widely used and is accepted as the most efficacious platin compound; however, its use is limited by its toxicity profile, especially nausea/vomiting and nephrotoxicity.
One of the most efficacious of these compounds is 2-methoxyoestradiol-3,17 2-methoxyoestradiol-3,17 2-methoxyoestradiol-3,17
However, our current results indicate that chronic, every other day treatment with CD, even when initiated post-weaning, proved significantly more beneficial than single [16], [19] or weekly injections of CD began at P7 and is the most efficacious of any compound tested to date in delaying NPC disease.
Collectively, these data support the current understanding that D3T is the most efficacious of the three compounds, with the observed efficacies of D3T ⋙ TBD ≥ OLT.
These actions are relevant to understanding how aromatic aldehydes may affect RBC membrane permeability per se as well as HbS polymerisation and thereby inform design of compounds most efficacious in ameliorating the complications of SCD.
EE and TAM doses were selected based on UWW dose response studies which identified 100 μg/kg as the most efficacious dose for each compound.
Compound 27 was most efficacious, which at a very low dose of 0.5 mg/kg reduced the time of immobility by 86.5% as compared to the standard drug fluoxetine (FXT) which reduced the immobility time by 69.8% at the dose of 20 mg/kg, ip.
Both via po and ip administration, compound 57 was the most efficacious in terms of decrease of parasitaemia.
