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Trials are ongoing to address the best sequence of the most efficacious combination chemotherapy to be given either before or after preoperative chemoradiotherapy.
Combination of resveratrol (0.1 μM) and baicalein in medium concentration (0.2 μM), with NADH in high concentration (0.8 μM) was found to be the most efficacious combination among all the 30 runs performed using OACD.
The most efficacious combination of total daily dose and dosing interval for the primary endpoint was HU 300 mg twice daily (P = 0.017).
Measurement of nNO merits to be part of a revised diagnostic algorithm with the most efficacious combination of tests to achieve PCD diagnosis.
Furthermore, the high overall diagnostic accuracy of nNO calls for re-evaluation of the diagnostic accuracy of each of the available diagnostic tests for PCD (nNO, TEM and HSVM) with the aim to develop an algorithm with the most efficacious combination of tests to achieve PCD diagnosis.
As in practice, treatment will be postponed until overt signs are present; we also administered the most efficacious combination of obidoxime (3.1 mg/kg) and atropine (3 mg/kg) at 10 min after poisoning with 30 μg/kg soman, when toxic signs were already visible.
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Table 3 summarises the outcomes and median dose used for the different combination therapies, and Fig. 2 illustrates the efficacy data of the four most efficacious combinations.
The addition of atropine (3 mg/kg) to the most efficacious physostigmine/obidoxime combination showed no improvements compared to the combination without atropine (Fig. 5b).
The data presented here suggest that tigecycline or linezolid combined with clofazimine or cefmetazole should be the most efficacious drug combination for treating M. abscessus infections.
And these speculations may be the basis for treatment duration trials in this disease where the new, most efficacious FU+oxaliplatin combination cannot be tolerated by a large proportion of patients because of cumulative neurotoxicity.
The proportion of households with any of the three most efficacious security combinations mentioned earlier (WD, EWD or WIDE) has almost doubled (84%) from 1998 (when comparable data exist) to 2011/12.
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