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N-acetylcysteine was the most efficacious agent, with 4/4 studies indicating a decrease in oxidative stress and one trial (n=134) showing reduced CVD events.
Beta-lactams are rarely effective, with exception of ceftazidime, which is the most efficacious agent against multiresistant strains.
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However, well controlled studies are needed to determine the role of post-injury antimicrobials and the most efficacious agents that also limit selection of increasingly resistant pathogens [ 38].
These studies included comparisons with olmesartan, which itself appears to be one of the most efficacious agents in the class 21,22.
In the present analysis, LMWH plus GpIIb/IIIa inhibitor or unfractionated heparin plus GpIIb/IIIa inhibitor were the most efficacious agents with the lowest risk for ischemic outcomes, but this occurred at the expense of an increase in bleeding.
Thus, results from an in vitro susceptibility testing are an important tool to guide a veterinarian in selecting the most efficacious antimicrobial agent(s) for therapeutic and prophylactic intervention.
Such is the case for antifungal prophylaxis in alloHCT recipients: while the most efficacious oral agent is currently unknown, a choice must still be made in those patients who are deemed to benefit from a prophylactic approach.
Opioids remain the most efficacious pharmacological agents for various clinical pain syndromes.
Some observations are possible, however, regarding levels of response seen with the most efficacious endocrine agents available today, albeit in less heavily pretreated patient populations.
27– 30 It is well recognized that selective 5HT3 receptor antagonists (ondansetron, granisetron, dolasetron, tropisetron, palonosetron) are the most efficacious antiemetic agents in CINV.
The use of MG has received considerable attention for its illicit use as one of the most efficacious antifungal agents in the aquaculture industry (Cha et al. 2001).
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CEO of Professional Science Editing for Scientists @ prosciediting.com