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Darwin's theory should be given primacy in the scientific education of our youth not because it is inherently true, but because it has the most effective predictive power of all competing theories.
Multivariate binary logistic analysis showed that TFF3 was the most effective predictive biomarker (P=0.000).
In Valentini's recent pooled analysis of seven chemoradiation trials, the most effective predictive model for developing local recurrence was based on ypT stage, cT stage, age, ypN stage and concomitant delivery of adjuvant chemotherapy.
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It may be possible not only to identify profiles predicting relapse (prognostic profiles), but also to predict which treatments are most likely to be effective (predictive profiles).
It plays the most effective rule because it represents the predictive part in PHM, which enables no surprises for PHM users especially the maintainers.
For high-risk women, however, the question is not one of chemotherapy versus no chemotherapy, but rather a question of which chemotherapy agent(s) will be most effective for which patients – a true predictive indication.
Meanwhile, the predictive capabilities of the most effective HQSAR and topomer CoMFA models were tested and verified via an external test set with 15 compounds, and then compared with those of previously reported models.
However, this factor accounted for only a small percentage of the variance and it accounted mostly for the low frequency components of the difference, i.e. the region where the predictive feedback component is most effective (see Fig. 9).
Finally, we sought to determine which measures were most effective (i.e., sensitivity and negative predictive power, NPP) for evaluation of malingering.
However, there is little if any comparative data to help choose the most effective drug to improve patients' outcomes, and predictive biomarkers of treatment response are also lacking [ 20].
The two main goals over the next 5 10 years in mRCC are to firmly establish the most effective agents in each class and identify predictive biomarkers associated with clinical benefit to specific agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com