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In contrast, the preferential elimination of the CSC population may contribute to the effectiveness of TMZ, which is the most effective pharmacologic agent used in glioma treatment; however, the activity of TMZ appears to be short lived because the drug causes the reversible blockage of the cell cycle of CSCs.
Considering that TMZ is the most effective pharmacologic agent used in glioma treatment and has partial and reversible effects on CSCs, the effect of a combined treatment with TMZ and the A1AR or A2BAR ligand on the survival of CSCs was then examined.
Furthermore, there is clear evidence that signaling pathways are targets of the most effective pharmacologic treatments for bipolar illness (Chepenik et al. [2010]).
For dyspnea, which is reported by patients receiving mechanical ventilation [64] as well as others with critical illness, opioids remain the most effective pharmacologic treatment and usually are therapeutic at much lower doses than are needed for pain [65, 66].
The administration of intranasal glucocorticosteroids is the most effective pharmacologic treatment in AR.
The most effective pharmacologic treatments include antidepressant, anticonvulsant and/or muscle relaxant medications (Goldenberg et al 2004).
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The results indicate that escitalopram is the most cost-effective pharmacologic treatment strategy for both regional health services compared with all SSRIs and all SNRIs used in the first-line treatment of major depressive disorder.
The results showed that the most cost-effective pharmacologic treatment from a societal perspective was escitalopram, dominating all the other comparators, while from a health care perspective, the cost per QALY of escitalopram was €3,732 compared with that of venlafaxine.
Selective serotonin reuptake-inhibitors (SSRIs) are currently the most widely used and effective pharmacologic agents in the treatment of panic attacks [ 6, 7].
A role of dopaminergic or other genes in smoking cessation is of particular potential importance, as research in this area may lead to the identification of subgroups of individuals for whom pharmacologic cessation aids may be most effective.
Although, the vast majority of ongoing clinical trials in GBM use drugs that predominantly inhibit HDAC class I enzymes (valproic acid, vorinostat, belinostat, entinostat, panobiostat 6,22,23,24, pharmacologic inhibition of HDAC class I enzymes may not be the most effective approach to potentiate TMZ and radiation therapy of GBM.
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