Sentence examples for most effective mutation from inspiring English sources

In silico predictions were tested in vitro, and the most effective mutation, T98R, was shown to improve antibody affinity for the mouse ortholog of the enzyme 14-fold, resulting in an inhibitor with a KI of 340 pM.

In those cases, probably only the most effective mutation conferring resistance is selected.

Therefore, we determined that the most effective mutation filter is presence of a sequence variant in more than two isolates.

R25E was the most effective mutation, extinguishing RecX-dependent inhibition almost completely even at the highest concentration tested (0.8 μM; 1 2.5 ratio of RecX to RecA).

The most effective mutations identified in the current study (R66G and R66I) are probably prl alleles.

The results of the strand-exchange inhibition experiments confirmed that R25E is the most effective single-point mutation in compromising RecX function, whereas the R145M mutant displayed only a mild impairment and the K35E, R127E, K128M mutants behaved similar to wild-type RecX.

However, in multivariate analysis, CKs were not found to be independently associated with BRCA1 or BRCA2 mutation status, and the most effective predictors of BRCA1 mutations were age at onset, HER2 status, and either ER or PR status.

If we assume that most ssRNA viruses have effective mutation rates within the same order of magnitude, a realistic mutation rate for the viruses included here might be something like 2.0 × 10-3.

Researchers from the Hotta group at Kyoto University, Japan, have shown that exon knock-in in DMD-patient-derived cells was the most effective way to correct mutations in the dystrophin gene, compared to exon skipping and frameshifting technologies.

In this study miR-P16 was found to be the most effective pri-miRNA, demonstrating highly effective mutation-specific atxn7 silencing in both the hemizygous situation and in the heterozygous cellular model (Figures 6B and Figure S3).

N-ethyl-N-nitrosourea (ENU) has long been known as the most effective method to introduce heritable mutations in the mouse [13].