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But the 52 percent response rate seen in the Merck trial was essentially the same as that seen with the most effective doses of a combination of two Bristol drugs — an already approved immune-based drug for melanoma called Yervoy, and the company's experimental PD-1 inhibitor, nivolumab.
Research studies to determine the most effective doses and modes of oral sucrose administration are ongoing.
Plasma insulin levels significantly increased in rats treated with 20 mg/L AA only or 10 mg/L AA plus 10 mg/L zinc, but not in rats treated with 20 or 30 mg/L AA plus 10 mg/L zinc, which are the most effective doses for the improvement of clinical signs of diabetes in G-K rats.
This was determined based on preliminary studies, and reflected the most effective doses.
The efficiencies of different MLL (MLL1 MLL4 -specific antisense oligonucleotides and their MLL1 MLL4 -specifics were studied.
The most effective doses of flesh extract were 10 and 20 μl per 4 mL of cell culture medium.
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We next examined the effects of the most effective dose of spirulina (125 ng/ml) and or NT-020 in the presence or absence of TNFα to determine if the effects observed in vivo to promote neurogenesis would be observed in vitro.
The most effective dose of TSL1 was 0.1 g/kg orally, with the effect beginning 30 min before treatment and persisting until 6 h.
Other effective mAb have entered the clinical realm without much preclinical data to show what may be the most effective dose, interval between doses, route of administration, or the effect of other critical factors such as tumor size.
Additional experiments were required to investigate the persistence in urine samples over a broader time period, to determine the most effective dose per day and to determine if the urinary anti-adhesion effect following cranberry is detected within volunteers of different origins.
By identifying the most effective dose (750 mg/kg) of PSC aqueous extract from previous experiments, the antidiabetic effects of PSC aqueous extract were assessed for 21 days in diabetic rats.
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