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The most effective compounds in mice were tested after oral administration in rats.
The most effective compounds known against scrapie in vivo are inhibitors of PrP‐res in infected cells.
Among which, 9d, 9f and 9g were the most effective compounds with GI50 values of 2.60, 2.81 and 1.29 μM, respectively.
Evidences of cell cycle arrest and apoptosis induction were obtained for the most effective compounds 27 and 34 by means of flow cytometry and microscopic techniques.
Aluminium and lanthanum modified compounds are among the most effective compounds for targeting P. Flocculants and ballast compounds can be used to sink cyanobacteria, in the short term.
The most effective compounds have shown the ability to enhance the anti-tumour efficacy of agents that kill better-oxygenated cells, i.e. radiation and standard cytotoxic chemotherapy agents such as cisplatin and cyclophosphamide.
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The most effective compound was trans-2-hexanal.
The hypolipidemic potency of the most effective compound HY-2c was further tested in vivo by hamster.
Among all these conjugates, one of the compound 5c could be considered as the most effective compound particularly against MCF-7 breast cancer cell line.
The most effective compound 11d with good enzyme-selectivity exhibited most powerful inhibitory potency against E. coli PDHc-E1 (IC50 = 0.97 μM) and cyanobacteria (EC50 = 0.83 μM).
Moreover, cells treated with most effective compound (4q) show up-regulation of p53, p21 and down-regulation of HDAC-1, HDAC-2, HDAC-5 and EZH2 mRNA levels.
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