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The most effective compound was trans-2-hexanal.
The hypolipidemic potency of the most effective compound HY-2c was further tested in vivo by hamster.
Moreover, cells treated with most effective compound (4q) show up-regulation of p53, p21 and down-regulation of HDAC-1, HDAC-2, HDAC-5 and EZH2 mRNA levels.
The most effective compound 36 inhibits Aurora kinases in vitro in the nanomolar range and diminishes HCT 116 cell viability blocking cytokinesis and inducing apoptosis.
The most effective compound 11d with good enzyme-selectivity exhibited most powerful inhibitory potency against E. coli PDHc-E1 (IC50 = 0.97 μM) and cyanobacteria (EC50 = 0.83 μM).
Data show that the most effective compound studied was the guanine derivative PMEGpp (IC50 12.7 ± 0.5 μmol L−1 at 125 μmol L−1 deoxynucleoside triphosphates (dNTPs)).
Similar(33)
The most effective compounds in mice were tested after oral administration in rats.
The most effective compounds known against scrapie in vivo are inhibitors of PrP‐res in infected cells.
Aluminium and lanthanum modified compounds are among the most effective compounds for targeting P. Flocculants and ballast compounds can be used to sink cyanobacteria, in the short term.
Among which, 9d, 9f and 9g were the most effective compounds with GI50 values of 2.60, 2.81 and 1.29 μM, respectively.
Evidences of cell cycle arrest and apoptosis induction were obtained for the most effective compounds 27 and 34 by means of flow cytometry and microscopic techniques.
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