Sentence examples for most driver mutations from inspiring English sources
Our analysis also shows that, for most driver mutations investigated here (IDH1/2, ATRX, TP53), tumor grade remains a prognostic factor in diffuse gliomas with identical driver mutations.
In the case of strong selection for additional driver mutations, the growth of the most aggressive clone (the clone with the most driver mutations) is very rapid, so that many cells that are 'susceptible' to acquiring the next driver mutation are rapidly produced.
The clone with the most driver mutations (termed the most aggressive clone) accrued a significant number of driver mutations prior to developing a mutator phenotype; when additional driver mutations caused large increases in fitness, the number of driver mutations accrued prior to a mutator phenotype increased (Fig. 5C).
Fourth, and perhaps most intriguingly, driver mutations tend to be specific to individual paediatric cancer types, with minimal overlap across diseases.
Vogelstein predicts that most new driver mutations will be rare; and nearly all will be part of same 12 pathways.
KRAS mutations are the most common driver mutations in lung adenocarcinoma (Pao and Hutchinson, 2012).
Mutations in genes in the Ras gene family are among the most common driver mutations found in human cancers.
Epidermal growth factor receptor (EGFR) gene mutation is one of the most pervasive driver mutations in non-small cell lung cancer (NSCLC), particularly in adenocarcinoma [ 1].
Second, we re-analyze in the interaction network all detected copy number and single nucleotide alterations and present the most likely driver mutations within each genome.
Importantly, IL-8 was shown to be upregulated in human cancers including NSCLC harbouring the oncogenic KRAS mutation (Sparmann and Bar-Sagi, 2004; Wislez et al, 2006; Sunaga et al, 2012), which is one of the most common driver mutations in lung adenocarcinoma (Pao and Hutchinson, 2012).
The KRAS mutation remains the most common driver mutation in patients with non-small cell lung cancer (NSCLC) and confers a poor prognosis.
