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That center seat is unusual, since most driver seats in existing vehicles are obviously offset to the left.
Our analysis also shows that, for most driver mutations investigated here (IDH1/2, ATRX, TP53), tumor grade remains a prognostic factor in diffuse gliomas with identical driver mutations.
Indeed, with a few notable exceptions such as TP53 and KRAS, which show consistently high mutation rates in many cancers, most driver genes harbor surprisingly few mutations (Vogelstein et al., 2013; Wood et al., 2007).
The sets of significant targets of most driver TFs differ widely between tumor types (Fig. 4a and Additional file 5: Table S7), with the notable exception of NFE2L2 and, to some extent, TP53, MYC (Fig. 4b), PAX5, and RUNX1.
Our central result is that beyond low impact thresholds approximated by the Darwinian fitness of the subclone with the most driver mutations little additional control is achieved when resistant subclones are present or likely to emerge during the long-term intervention assumed here.
In the case of strong selection for additional driver mutations, the growth of the most aggressive clone (the clone with the most driver mutations) is very rapid, so that many cells that are 'susceptible' to acquiring the next driver mutation are rapidly produced.
Similar(51)
That philosophy was applied to the S4 and S5, too, and those cars are among the most driver-pleasing Audis of recent times.
So, they shut down a 10-mile stretch of one of the world's busiest freeways for repair last weekend, in the nation's most driver-stressed metropolis, and gave it a scary name - Carmageddon.
Most drivers do this.
Most drivers seemed pleased.
Most drivers disappear quickly after qualifying.
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