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EIN3 acts as a positive regulator at the most downstream position of the ethylene signal transduction pathway [ 74].
This data gives the most upstream position of variant start sites and the most downstream position of variant end sites.
In this analysis, -13 is the position for an average from -20 to -6 that covers a region from -20 to -1, so -13 is the most downstream position.
For this analysis, pathway position was defined as the number of steps required to transduce the signal from the most upstream element (Grb2, position 0), to each of the pathway components (with proteins RSK1 3 sharing position 6, the most downstream position of the core pathway; Figure 2A; Additional file 1: Table S5).
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They typically have a peak at the most downstream region of the promoter (position -13, Table 1), but peak positions distribute from -13 to -60.
The inability of λcI to effectively act as a repressor when bound to a single operator at the downstream position is most probably caused by its inability to effectively compete with RNA polymerase binding at this position [13].
Lake Ontario is the most downstream of North America's Great Lakes and it is positioned between Canada's Province of Ontario and the USA state of New York.
When several clustered positions fulfilled this condition, only the most downstream was considered as the mRNA end.
In contrast, most downstream flows go into dollars and euros.
Most downstream genes were specifically up-regulated in each overexpressor.
Au-coated silicon substrates were placed at the downstream position of the source material.
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