Sentence examples for most downstream component from inspiring English sources
Here we explore the effects of reducing the activity of Drosophila Vps4 (dVps4), the most downstream component of the ESCRT machinery.
Here we report that disruption of the ATPase dVps4, the most downstream component of the ESCRT machinery, causes the same array of cellular phenotypes.
We next focused on addressing whether the Shh-VEGF-Notch-hey2/grl pathway influenced the FEVPs population at the LPM, beginning with the most downstream component, hey2/grl.
The most downstream component of the SIN is the Sid2p-Mob1p kinase complex whose enzymatic activity peaks during cytokinesis in a SIN dependent manner.
EAK-7, which is likely the most downstream component of the EAK pathway, is a conserved protein of unknown function that is expressed in the same tissues as DAF-16/FoxO.
Based on the observed transcript changes, the phosphatase Tps2 is predicted to be the most downstream transcriptional component and the regulatory subunit Tsl1 is suggested to play an important role in communicating feedback.
It was also reported that miRNAs predominantly target positive regulatory motifs, highly connected scaffolds and most downstream network components such as signaling transcription factors, but less frequently target negative regulatory motifs, common components of basic cellular machines and most upstream network components such as ligands [ 32].
Tps2 and Tsl1, two enzymes involved in the biosynthesis of the storage carbohydrate trehalose, are predicted to be the most downstream transcriptional components.
The results indicate that pathway members involved in the biosynthesis of the storage carbohydrate trehalose, Tps2 and Tsl1, are the most downstream transcriptional components.
To further determine whether members of the metabolic pathways are indeed the most downstream transcriptional components, a new approach was applied to deduce the hierarchy of transcriptional regulation within the glucose regulatory system (see Methods).
By analyzing the interactions between miRNAs and cellular signaling networks, miRNAs were found to predominantly target proteins of the same signaling pathway and target highly connected scaffolds and most downstream network components such as signaling transcription factors.
