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This focus on empiric "most dose with acceptable risk" may be misguided for mechanism-targeting new agents, and this could lead to unnecessary delays, increased costs and even higher risk of missing important signals of activity and benefit.
Most dose interruptions/reductions occurred in early cycles.
Most dose adjustment occurred in the first 4 weeks in both groups (Fig. 1).
Most dose investigation studies are clinical trials (83 of 97) that evaluate a single dosing rule.
Diarrhoea, nausea and vomiting occurred at most dose levels, but tended to be dose dependent.
Most dose assessments have been done with oral or rectal administration of artesunate (13, 64, 65).
Similar(42)
The group noted that this would require using "the most dose-sparing formulations," which means adding vaccine boosters called adjuvants; approved flu vaccines in some countries, including the United States, do not use adjuvants.
Most doses are generally administered early in the influenza season, yet sustained vaccination efforts are crucial for achieving optimal coverage.
Compliance was initially high but decreased progressively in children who were required to take the most doses.
61 Most dose-limiting toxicities (DLTs) are fatigue, nausea, and somnolence.
Among them, RP is one of the most dose-limiting toxicities and acute complication for thoracic radiotherapy of esophageal cancer [ 1– 5].
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