On the other hand, a combination of the three most diverse loci (DYS464, DYS385 and DYS390) has the same capacity to distinguish between paternal lineages than the complete minimal haplotype (minHT) consisting of eight Y-STR loci.
The two virulence factors, gtfB and spaP, were amongst the most diverse loci investigated but there was no evidence for the positive selection of any amino acid [codon] as determined by the SLAC analysis although for both of these alleles the number of nonsynonymous changes was greater than the number of synonymous changes.
They found that the combination of these methods (which requires including >15 of the most diverse loci for MIRU-VNTR analysis) has comparable discriminatory power to IS 6110 RFLP typing (22 ).
That the least polymorphic locus identified in the present study (fnVNTR-2) was among the most diverse loci identified in isolates from wild cod [ 11], suggests that the discriminatory power of the present assay for F. noatunensis subsp. noatunensis may be underestimated.
The current method types the four most diverse HLA loci: HLA-A, B, C and DRB1.
Additionally, after examining some of the most diverse human loci, we find that exon-capture is able to enrich and facilitate high-resolution analysis of highly polymorphic HLA and KIR genes from DNA extracted from human saliva.
The HLA are the most genetically diverse loci in the human genome [4].
HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses.
We also demonstrated that two putative virulence determinants, glucosyltransferase B [gtfB] and surface protein antigen I/II [spaP], were the most diverse of the loci investigated here and that, unlike the house-keeping genes the recombination/mutation ratios were <1 indicating that mutation and not recombination was the driver of diversity in these genes.
