In the following analyses, we focused on the two most divergent classes (HCP and LCP).
On the other hand, the most divergent KEGG classes were about metabolism, such as Metabolism of xenobiotics by cytochrome P450, Glutathione metabolism, and Ascorbate and aldarate metabolism (Table 6).
We also identified hundreds of highly diverged genes and compiled sequence identify data into gene functional groups and found the most divergent gene classes are Cytochrome P450, Glutathione metabolism and Oxidative phosphorylation.
Phocein belongs to the Mob3-like group, the most divergent clade of the five different mob domain classes, and is called Mob3 (Vitulo et al. 2007).
The eight isoforms of the PI3K family have a specific hierarchy with PIK3C3 (phosphoinositide-3-kinase, class III) the most divergent relative to PIK3C2 (phosphoinositide-3-kinase, class II) and PIK3C (phosphoinositide-3-kinase, class I) proteins.
Family I is the most divergent one among the three structural classes.
This class of genes exhibits the most divergent expression pattern in the two transcriptomes (r = −0.80) and is comparable in size to class 1. (3) Class 3 = Orthologs differentially expressed only in C. elegans dauers (n = 178 in C. elegans, Figure 1a) (4) Class 4 = Orthologs differentially expressed only in P. pacificus expression profile (n = 2626 in P. pacificus, Figure 1a).
Of the class IIa HDACs, HDAC7 is the most divergent [47], [61].
Of the three isoforms, PIK3C2G (phosphoinositide-3-kinase, class 2, γ polypeptide) is the most divergent and appears common to all species.
These proteins represent members of the Cif family that are most divergent in sequence from CifEc.
