"The property-casualty insurers had been among the most disfavored stocks on Wall Street," said Robert P. Hartwig, the chief economist at the Insurance Information Institute, an industry group in New York, adding that some had dropped below book value.
We found that the presumed consent system is the most disfavored among the options studied (we did not explore family involvement or differentiate between stringent and lenient systems).
For example, as illustrated in Figures 2c and 2d, when the frequencies of occurrence of each of the 1064 pentamers was determined, all of the 32 pentamers that contain only A and/or T were underrepresented relative to the presence in the genome sequences with ATATA (=TATAT) being the most disfavored pentamer in both Archaea.
As the approximate index of optimum codons, we used preferred codons, or most frequently used codon for an amino acid, and evaluated the preferred codon fraction in SCCSs.
Significantly, CTG codons were the most frequent CTN codons in codon-triplets that vanished from C. albicans and D. hansenii ORFeomes (Additional file 1, Figure S4A).
Amongst the various design parameters considered for the gene synthesis, codon context bias has been relatively overlooked compared to individual codon usage which is commonly adopted in most of codon optimization tools.
The codon-anticodon adaptation hypothesis [17] [20], [23], [26] predicts that the anticodon should match the most abundant codon.
In other words, the tRNA anticodon should evolve to match the most abundant codon in a synonymous codon family.
Most used codon is UUA (Leu), while less used codon is CGC (Arg).
Frequencies shown in bold indicate the most common codon (where synonymous codons exist for that amino acid or termination).
