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The most direct experiments would involve investigations of axial force generation and/or membrane tension changes in individual stereocilia under somatic voltage clamp conditions with the MET channels blocked.
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Although they yield the most direct evidence, field experiments present difficulties, since the leaders and members of such organizations may effectively resist the intervention of experimenters.
Measuring health outcomes among children whose mothers participated in randomized trials during pregnancy is not only the most direct way of confirming animal experiments of prenatal programming, but also may reveal how to improve child and adult health outcomes by intervening at early stages of human development.
On the other hand, in vivo experiments present the most direct application of engineered circuits, but involve long time scales and the results are often difficult to interpret.
Mutation-accumulation (MA) experiments provide the most direct way to examine the consequences of new mutations, but most studies have focused on juvenile viability without regard to sex, and on autosomes rather than sex chromosomes; both adult fitness and X-linkage have been little studied.
Animal experiments showed that cadmium's most direct effect on brain metabolism is to inhibit a number of sulfhydryl-containing enzymes (Stowe et al. 1972).
One of the most direct experimental accesses to metabolic fluxes is provided by atom-labeling experiments (Wiechert, 2001; Sauer, 2006).
While such experiments would involve quite an investment, they might be the most direct way to assess effective pollution exposure at the population level.
Direct validation by in-vivo experiments using available kinase inhibitors may in some cases be the most direct approach since synthetic lethality screening itself needs such validation because of off-target effects.
Finally, we carried out an experiment whose aim was to test our prediction in the most direct way.
For most biochemical pathways with known topology, most reaction rate constants (i.e. the coefficients of the differential equations) are not available from direct experiments.
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CEO of Professional Science Editing for Scientists @ prosciediting.com