In the simplest and most direct cases where a functional homolog of the affected protein in human exists in yeast, the identified mutations can be introduced at synonymous positions in the considered gene, as in neuropathy, ataxia and retinitis pigmentosa (NARP) syndrome, a devastating mitochondrial disease [ 6].
There, in a speech the public would never hear, he offered his most direct and impassioned case for allowing gays to wed.
The most direct parallel with this latest case is that of Fang Lizhi, a Chinese astrophysicist and government critic, who took refuge in the US embassy in Beijing in 1989, just as the authorities were launching their crackdown on the Tiananmen protests.
In this case, the most direct fix is usually to add copper-based anti-parasite additives to the water and to improve the water quality with the tips above.
The case poses the most direct confrontation yet between the Endangered Species Act, which ranks the protection of threatened animals and plants above human needs, and the water rights held by cities like Albuquerque in Western states where water is becoming increasingly scarce.
Most direct costs were based on 179,718 cases of influenza identified in the Medstat Marketscan database between 2000 and 2004.
For spatial clustering of BSE cases, the perhaps most direct mechanism would be regional differences in disease surveillance intensity.
Direct validation by in-vivo experiments using available kinase inhibitors may in some cases be the most direct approach since synthetic lethality screening itself needs such validation because of off-target effects.
This is generally the most direct way to request records for a single specific case.
More recently, the most direct evidence of zoonotic transmission yet available was described in a case study from Japan.
