Many laboratories offer this test but most will use a direct assay (antibody coated-tube, radioimmunoassay) not appropriate for paediatric investigations.
Because this is by far the most direct and reliable NMR-based assay, it is our opinion that these methods should be the preferred approach to either hit identification or hit validation when initial putative hits are selected by other methods.
IC50s of the most potent compounds against AfAGM1 were estimated using the direct assay method described above.
The most direct and specific diagnosis of NCLs relies on enzymatic assays in biological samples such as leukocytes or cultured skin fibroblasts, using radiometric or fluorescence detection.
Throughout most direct antiviral agent (DAA) approval studies, HCV RNA cutoffs and endpoints were established with the COBAS TaqMan assay for use with the High Pure System (HPS/CTM).
Because the most direct method of demonstrating cell fusion is to ascertain mixing of cellular constituents of the interacting partners, these assays have in common the measurement of a new signal output only after such mixing occurs.
The most direct evidence to support our hypothesis would be to demonstrate the function of mtRF1 in a vertebrate mitochondrial translation termination assay.
However, the most direct way to have an overview of the complex reactions and effects caused by the fungal metabolites in plants is to assay the natural mixtures.
NMR spectroscopy was the most direct method to provide proof of ACTase activity; radioactive tracer analysis was the most sensitive technique and a microtitre-based colorimetric assay was the most cost-and time-efficient for large scale analyses.
Rios took the most direct responsibility.
