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In vitro binding studies using purified GST-Gravin fragments mapped a central region of the anchoring protein (amino acids 451 to 900) that directly interacts with Aurora A. More detailed mapping studies defined at least two extended Aurora A-binding sequences within this region, thus eliminating site-directed mutagenesis as the most direct approach to disrupt the Aurora A-Gravin interaction.
"Come to Leave," the more allusive and abstract of the two, actually takes the most direct approach to escaping from grief.
Two Democratic senators, Barbara Boxer of California and Jon S. Corzine of New Jersey, have taken the most direct approach, saying workers should be prevented from holding any more than 20percentt of their 401(k) assets in company stock.
If one were to use rat urine – the most direct approach – the would-be poisoner would need access to a microbiological laboratory to ensure that the rats in question carried the bacteria, Croft said.
The most direct approach of controlled synthesis of NWs is produced by electrochemical routes [13].
Worse still, it was misty and a church steeple blocked what would have been the most direct approach.
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One of the most direct approaches to model the evolution of deep water waves is the use of nonlinear Schrödinger equation (NLS [1, 2].
Identification of age-dependently expressed genes is one of the most direct approaches in ageing research.
ABM is the most direct initial approach to simulate the temporal evolution of a complex system and to encode complicated time-dependent cellular and molecular events that occur during inflammation and wound healing [58] [61].
The most direct experimental approach is by examining PGs' biosynthesis upon COX-2 inhibition.
A pre- versus post-dam comparison would provide the most direct study approach, but pre-dam information is limited to historic reports and archival photographs.
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