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And by far the most difficult to construct without an algorithm.
The design was among Alessi's most difficult to construct, as it is built like a thermos, with four layers of titanium to keep the exterior cool to the touch.
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Major randomized controlled trials to determine the most effective antibiotic prophylaxis are difficult to construct and interpret.
A monetary valuation scheme is the most straightforward, but it may be difficult to construct such a scheme that adequately represents all aspects of the decision.
Furthermore, most of the plate is submerged, rendering it difficult to construct a virtual geomagnetic pole (VGP) path using fully oriented paleomagnetic samples.
Despite the apparent conceptual simplicity of this approach, it is difficult to construct such networks, and most of the miRNA and TF mediated interactions are not yet well-characterized.
As it is computationally difficult to construct a phylogenetic tree for more than a few thousand taxa, most analyses focus on a taxonomically-restricted subset and select a few exemplars from each group (e.g., [3], [4]).
We may find it difficult to construct sentences, to make ourselves understood clearly or engage with people other than those most familiar with us.
However, most indicators were not developed on the basis of soil loss progresses, and therefore their specific relationships with soil loss are difficult to construct.
"It's not very difficult to construct".
But these plants are hellishly difficult to construct.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com