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The most difficult symptoms of asthma were shortness of breath (mean rank = 7.2), followed by chest tightness, coughing, and wheezing (6.7, 6.3, and 6.0, respectively).
One of the most difficult symptoms of CP is severe abdominal pain, which is often challenging to control with available analgesics and therapies.
Symptom management and support in hospice is rated higher even than the palliative care unit likely because the unit is reserved for patients with the most difficult symptoms, physical and psychosocial.
BPSD are among the most difficult symptoms to treat, a primary source of caregiver stress, strongly associated with carer burden and depression and one of the main drivers for placement breakdown and admission to residential care facilities [ 7- 12].
Dementia is a complex brain syndrome with a spectrum of cognitive, functional, behavioral, and psychological symptoms that reduces quality of life for both patients and their informal caregivers. 1, 2 Behavioral and psychological symptoms related to dementia are among the most difficult symptoms of the syndrome to manage.
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Pain was the most difficult symptom to categorize as being caused by hyponatremia, as it may be caused by the surgery itself.
The most difficult symptom to treat in this series was dyspnoea with a response rate of 6 out of 13. Figure 1 illustrates the objective responses in one of the patients.
The symptom of cough is one of the most difficult respiratory symptoms to treat and only a little is known about the exact mechanisms in children and adults [ 6- 8].
The adolescent group's most difficult reported symptom was fatigue (mean rank = 7.4), followed by chest tightness, wheezing, and coughing (6.6, 6.5, and 6.3, respectively).
The clinical spectrum of CD has been expanded in recent years, with the identification of asymptomatic patients, patients with minimal symptoms (the most difficult to detect), and patients with extra-intestinal symptoms [2] [5].
Predicting progression to disease is most difficult in individuals with early symptoms or mild pathology, but prediction in this population is clinically highly relevant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com