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Diaurate complex 8 is the most difficult compound to be oxidized of the series.
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The feed contained some of the most difficult to remove sulfur compounds such as 4-methyldibenzothiophene (MDBT), 4,6-dimethyldibenzothiophene (DMDBT).
The HSP dataset was the most difficult for scoring, as active compounds did not contain remarkably populated HB contacts.
Without doubt, the assessment of compound similarity is the most difficult task for activity cliff definition and analysis, for several reasons.
Many, such as Harvard's William Liller, warned of serious consequences for astronomy: "Substantially increased dipole densities, as the operational belts will very likely have, will make any research on faint astronomical objects most difficult except from above these belts," he wrote – a problem compounded by the location of the ring being classified.
However, 1d, which is the most difficult to be reduced among the cumulenes studied, did not give sulfur-containing organic compounds.
Total disappearance of the parent compounds and 90% mineralisation have been attained with all pesticides tested, methomyl being the most difficult to be degraded with both treatments.
The most difficult decision.
Dinner is the most difficult.
Ms. Minor's most difficult task?
The most difficult opponent?
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