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In contrast, basal-like and Her2 amplified or over-expressing samples exhibited the most differential intron retention relative to normal tissue, as well as the strongest bias towards decreased intron retention.
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In contrast, differential intron retention is the most widespread form of AS found in non-metazoan eukaryotic species (McGuire et al., 2008).
The Supplemental Figure 3, for example, demonstrates that differential intron expression analysis suggests additional intron retention events under heat stress.
The difference in exon/intron-structure among homologous genes is then considered to be mostly due to differential intron loss.
Two HGT genes originating from fungi (ankp and deha) seem to have differential introns to that of the most probable donor, while the other two HGT genes (acsf and sdrp) originated from bacteria and new introns were directly inserted into the HGT genes.
Chromosome 19 is the most minimal intron-enriched chromosome (with 18.7% of total introns, P = 3.7×10−196), but chromosome 18 is among the most minimal intron deficient (with 4.0% of total introns, P = 5.1×10−26).
In most eukaryotes, intron loss is much more common than intron gain [ 41- 44].
The most conserved intron was a phase 2 intron at position 1368; this was present in 45 CCEs.
The most important differential diagnosis in gout is septic arthritis.
During this period, the species with the most intron losses was Saccharomyces cerevisiae (255 introns), and the species with the fewest losses was Homo sapiens (57 introns).
Therefore, most important differential diagnosis was rhabdomyosarcoma.
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