Sentence examples for most destabilized from inspiring English sources

Still, it is not clear whether most destabilized proteins are detected and disposed in this way.

Indeed, most destabilized proteins must be sequestered by the molecular chaperones because there are relatively few unfolded or partially unfolded polypeptides in the cytosol [ 58].

Interestingly, these data show that the UPR is activated by the most destabilized amyloidogenic variants, which also display a distinct rough-eye phenotype (Fig. 6 D, E).

Five of the seven super-Spy variants were significantly less thermodynamically stable than the wild-type protein (Table 2), with mutant L32P being the most destabilized (ΔΔGNU = −3.25 kcal mol−1).

The new form will allow the conscientious taxpayer to check off one-dollar contributions to (1) the American election campaign, (2) the Italian election campaign, (3) the Angolan regimental band of his choice, and (4) the Latin-American political entity he most wishes destabilized in Fiscal Year 1977.

Available substratum in most sites destabilized communities as expected, however, the effect of functional richness is more indirect than expected, i.e. it modulates the strength of the stabilizing effect of taxonomic richness.

The amount of amyloid formation is correlated with the effect of the mutations on stability: A4V, one of the most highly destabilized ALS mutants, forms amyloid in very high yield, with less amyloid formed from the moderately destabilized G93A, and G85R, the least destabilized of the three mutants, forming virtually no amyloid.

Robetta was used to identify residues lying within potential dimerization interfaces in SecA crystal structures and to guide the selection of residues at which single-alanine substitutions are expected to most strongly destabilize dimerization.

As parameter fitting can be computationally expensive, by reversing the idea of robust performance and searching for target combinations which most easily destabilize the diseased state, the number of parameter fittings performed early in the analysis can be greatly reduced [ 34].

We therefore hypothesized that brain neurons possess αSyn tetramers and related multimers but that either our purification method is biased toward the monomeric αSyn population or most multimers are destabilized to unfolded monomers at some point during the purification.

The most frequent highly destabilized cancer-associated mutant, R175H, has, however, eluded a detailed structural characterization, indicating the need for complementary techniques to study this and other unstable mutants.