Using similar tools (PolyPhen 2.0, SIFT, PANTHER, I-mutant 3.0, PhD-SNP, SNP&GO, Pmut, and Mutpred) they found that R326H and R356Q are the most deleterious mutations associated with Oculocutaneous albinism type III (OCA3) disease.
Among the variety of types of DNA damage, the most deleterious is the DNA double-strand break (DSB).
Published: November 12, 2015 Among the various DNA damage types, DNA double-strand breaks (DSBs) are the most deleterious since they can lead to various mutations and chromosomal rearrangements linked to tumor initiation and progression.
Among the different types of damage, DNA double-strand breaks (DSBs) are considered the most deleterious, because they can cause cell death, a permanent proliferative arrest termed cellular senescence or, in checkpoint-impaired cells, genomic instability leading to cancer development.
Induction of skin cancer is the most deleterious effect of excessive exposure to sunlight.
Effects of extraterrestrial solar UV radiation: Solar UV radiation has been found to be the most deleterious factor of space.
The method successfully identified Jordan River Water as the most deleterious, and Treated Waste Water as the best, irrigation treatment when considering soil quality.
These organs have been subjected to a period of warm ischemia that is most deleterious to functional recovery.
Most deleterious of all is the hike in heating oil or Mazout.
Thus, cadmium seems to be the most deleterious among heavy metals in the mushrooms.
