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First, many neutral and most deleterious polymorphisms are expected to be rare and present only in a small number of strains.
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In coding regions, moderate and rare allele frequencies were particularly reduced (Table 4), as expected under purifying selection because it acts more strongly against rare polymorphisms, which include most deleterious mutations.
Thus, cadmium seems to be the most deleterious among heavy metals in the mushrooms.
Induction of skin cancer is the most deleterious effect of excessive exposure to sunlight.
While any color of light can suppress melatonin production, blue light is most deleterious.
UVB (290-320 nm) is the most deleterious component of sunlight on earth surface [2].
The most deleterious mutations were K65R, Q151M, M184V/I, and T215Y/F, each of them decreasing susceptibility to most of the NRTIs.
During mutagenesis studies in human SIFT can differentiate functionally neutral and deleterious polymorphisms [ 45].
Therefore, loss of RNAi sensitivity in Hawaii is consistent with ppw-1 deleterious polymorphisms [ 9].
If weak deleterious effects are rare, then we expect that most deleterious mutations are immediately removed from the population.
When interactions between deleterious polymorphisms dominate the dynamics of the populations, the asymptotic correction proposed by Messer and Petrov [ 32] can be used to correct for underestimation due to low and medium frequency deleterious polymorphisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com