The most deleterious form of DNA damage are DNA double-strand breaks (DSBs), which arise under physiological conditions predominantly from oxidative damage [1], or are caused by genotoxic insults such as ionizing radiation, and are repaired by non-homologous end-joining (NHEJ) and homologous recombination.
Intra-abdominal AT IAATT) is thought to be the most deleterious form of adiposity, and lower-body (or gluteo-femoral) subcutaneous AT (SAT), the least deleterious [ 28- 31].
The most deleterious form of DNA damage is the DNA double-strand break (DSB), which can be formed by free radicals derived from the metabolism, ionizing radiation, or DNA cross-linking agents or which can naturally occur during DNA replication.
To the best of our knowledge, DOB ICL analogue 7 is the only cross-linked DNA that is exclusively transformed into a double-strand break, the most deleterious form of DNA damage.
Because this infection is persistent and poorly responsive to antibiotics it is undoubtedly one of the most economically deleterious forms of M. bovis infection [ 13, 15].
The four mutations with the most deleterious effect on pVHL affinity all belonged to class 1 (L529P, A530T, P531A, Y532C; Fig. 4d, Table 2).
Induction of skin cancer is the most deleterious effect of excessive exposure to sunlight.
Effects of extraterrestrial solar UV radiation: Solar UV radiation has been found to be the most deleterious factor of space.
Tract housing, whose cookie-cutter structures and treeless vistas are perhaps the most deleterious realities of American domestic architecture, is a recurring motif here.
The method successfully identified Jordan River Water as the most deleterious, and Treated Waste Water as the best, irrigation treatment when considering soil quality.
