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Strikingly, however, the most deeply conserved genes are expressed at highest levels in human tissues that are the least conserved in structure and function, including placenta.
The 20 most deeply conserved sequences (> = 350 Myr) also appear to be associated with a specific class of genes.
The most deeply conserved CNEs detected to date originated before the divergence of deuterostomes and protostomes, only four examples of which have been found so far.
Most human ZNF genes, from the most deeply conserved to the primate-specific genes, are highly expressed in immune and reproductive tissues, indicating that they have been enlisted to regulate evolutionarily divergent biological traits.
We report the identification of the most deeply conserved CNE's found to date, and several other deeply conserved elements which are without exception, part of 5' untranslated regions of transcripts, and occur in a number of key translational regulatory genes, highlighting translational regulation of translational regulators as a conserved feature of insect genomes.
For the set of most deeply conserved snoRNAs identified here, we suspect that constrained drift best accounts for their genomic evolution.
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This group, together with the BTB/POZ genes, includes most of the deeply conserved polydactyl ZNF genes.
It is thus not surprising that cilia and most ciliary genes are deeply conserved, both in structure and function, in the "tree of life".
Most well-characterized enhancers are deeply conserved.
During evolution, significantly stronger selective constraints should impose on the deeply conserved miRNAs, whereas most species-specific miRNAs (young miRNAs) are expressed weakly, or in specific conditions or tissue types, more divergent, and tend to lack targets, suggesting a neutrally evolving path.
A specific prediction of the introns-first model is that snoRNAs are found in the introns of the most deeply-conserved protein-coding genes.
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