Because genetically monomorphic bacterial pathogens harbour little DNA sequence diversity, most current genotyping techniques used to study the epidemiology of these organisms are based on mobile or repetitive genetic elements.
Most current HPV genotyping assays rely on polymerase chain reaction amplification of a 60- to 450-base-pair region of the HPV L1 gene using consensus primers (i.e., targeting conserved regions of the gene).
Theoretically, TSP can be directly incorporated into the design of assays for most current single-marker SNP genotyping methods.
It should be possible to directly incorporate TSP into the design of assays for most current single-marker SNP genotyping methods.
Theoretically, TSP can be directly incorporated into the design of assays for most current single-marker SNP genotyping methods to provide enabling advances that simplify assay design and development, increase assay throughput, and improve assay automation and genotyping calling.
However, most technologies give only genotype information and most current research does not determine the haplotype origin of the variations.
Most current research focuses on DNA methylation and genotyping.
The successful nationwide implementation of the HPV vaccination program in Italy will probably change the frequency of the most prevalent genotypes, decreasing the prevalence of the current genotypes and increasing the possibility of HPV replacement following vaccination, as already described for several bacterial infections [ 24].
In most current large-scale genetic association studies, data are collected as unphased multilocus genotypes (that is, which alleles are aligned together on particular segments of chromosome is unknown).
Most current research does not determine the chromosomal origin of the variations and uses only genotype information for the analyses.
