Sentence examples for most critically involved from inspiring English sources
The assumption that the most critically involved genes tend to behave in a similar way between samples within each class is well founded in many cases, especially for single genes that cause rare diseases.
Therefore, the class III chitin synthase AfChsG was most critically involved in the response to caspofungin treatment.
Here, our aim was to investigate which of the different processes discussed earlier is most critically involved in apathy observed in healthy individuals.
Mechanisms underlying post-ischemic neuroprotection after acute stem cell transplantation imply a variety of different events, among which stabilization of the BBB and reduction in post-ischemic inflammatory responses are most critically involved.
The discovery that the transcriptional interactions most critically involved in the formation of long feedback loops in the cancer cell line K562 are also present in the longest incomplete feedback loops in the non-cancer cell line GM12878 may provide clues to mechanisms of cancer initiation and progression.
In this review article, we will discuss how significant advances can be obtained by applying computational modeling approaches to elucidate the pathways most critically involved in tumor formation and progression, impact of particular mutations on pathway operation, consequences of altered cell behavior in tissue environments and effects of molecular therapeutics.
Most are critically involved in the regulation of cell movement and invasion, as well as proliferation (Supplementary Tables S1 and S4).
This most likely reflects that in most cases of AML, KIT is not critically involved in sustaining abnormal proliferation, unlike BCR-ABL, which is pathogenetic in CML.
These different analyses suggest that the left inferior frontal gyrus, most robustly left BA 45, is critically involved in syntactic comprehension, though almost always in conjunction with left posterior middle temporal gyrus.
Most of these examples comprise genes critically involved in developmental processes, such as intercellular communication, intracellular signalling, or activation of cell-type specific gene expression, which is reminiscent of previous results stressing the over-representation of such functional categories in post-duplication retained genes [ 10].
The predictable integration of candidate enhancement species, most critically those involving introductions in targeted habitats, will benefit production, increase likelihood of securing sponsor and scientific community partnership and reduce project failure.
