Progesterone, acting through the progesterone receptor isoforms, PGR-A and PGR-B, is one of the most critical regulators of endometrial functions.
FOXO1, a member of the Forkhead family proteins of the O subclass, is not only one of the most critical regulators of cell death [ 12], but also an early molecular regulator during mesenchymal cell differentiation into osteoblasts.
The increased prevalence of obesity in present day society and the current view of adipose tissue as one of the most critical regulators of energy homeostasis and metabolism have warranted a sustained interest in studying the mechanisms controlling its formation.
Under the non-stressed condition, wtp53 protein levels are kept low in normal cells and tissues mainly through the proteasomal degradation mediated by E3 ubiquitin ligase MDM2, the most critical negative regulator for wtp53 (Brooks and Gu, 2006; Hu et al., 2012).
We reasoned that the restricted expression should be a general pattern for the most critical miRNA regulators of hTERT in various tumor cells.
Vascular endothelial growth factor (VEGF) represents one of the most specific and critical regulators of angiogenesis by regulating endothelial proliferation, permeability, and survival.
"He helped lead the organization through one of the most critical times for securities regulators and helped build and shape many of Finra's regulatory programs," Richard Ketchum, the organization's chairman and chief executive, said in a statement.
p65, one of the most important subunits of NF-κB, is a critical regulator of NF-κB transcriptional activity and associates with the development of HCC.
But remember that those "hacks" are our elected officials and it would seem downright undemocratic to give unelected regulators unfettered control over the most critical sector of our economy.
But after the Fukushima accident passed its most critical phase, the government moved to address public criticism of the Tepco and industry regulators by announcing reforms to the utility's management structure and a new nuclear watchdog - separate from the trade industry - that will start work this spring.
