Sentence examples for most critical pathway from inspiring English sources

Notably, among the chromatin mechanisms tested for a functional role in Xi-maintenance, DNA methylation so far appears to be the most critical pathway for maintaining the silent state of the Xi in differentiated cells [ 20].

These results, in conjunction with our observation that NHEJ mutants such as yku70, dnl4 and nej1 cells were not sensitive, indicate that homologous recombination is the most critical pathway in the S288c strain background used to construct the libraries.

The Fas/Caspase signaling pathway is one of the most critical pathways of apoptosis [ 43].

In conclusion, in this study, we demonstrate that PI3K signalling is one of the most critical pathways sustaining MDB cell growth and survival.

These two signaling cascades, which are the most critical pathways in cancer progression, are responsible for the aggressive phenotype of breast cancer [ 86- 88].

On the other hand, the PI3K/Akt signaling is one of the most critical pathways involved in the regulation of skeletal muscle mass [ 8, 12].

By developing country specific TOCs to define hypothetical pathways to improved product availability, we were able to use the baseline data to identify and validate the most critical pathways in the three focus countries.

As mentioned earlier Wnt signaling is one of the most critical pathways for cellular development, even in adult tissues; henceforth, the polymorphism in genes of Wnt signaling modulators can be a foremost cause for various types of associated diseases.

Hence, loss of p53 function fails to activate these genes after cellular stress and is thus thought to be a critical cause of tumorigenesis and/or tumor progression [ 26]. p53-dependent apoptosis is one of the most critical pathways of cell death in tumor-suppressive functions.

An examination of where in the income distribution income is most strongly associated with risk of mortality will provide guidance for identifying the most critical pathways underlying the connections between income and mortality, and may help to inform public health interventions to reduce socioeconomic disparities.

The most critical signaling pathway for the regulation of long-lasting memory formation is that containing CREB and its downstream targets.