Sentence examples for most critical limitations from inspiring English sources

However, development of drug resistance and dose-limiting toxicity are the most critical limitations of taxane therapy.

One of the most critical limitations in synthesizing starch-polyurethane (PU) hybrid materials is their microphase separation caused by physical incompatibility.

These two phenomena are the cause of what are probably the most critical limitations to the interpretation of long-term altimetric series in term of mass balance and to the comparison between or data fusion of different missions.

One of the most critical limitations in sex ratio studies is the ecologic study design, where the exposure is often unmeasured and unclear.

First, the most critical limitation is possible underestimation of stillbirths using pregnancy histories, as reported in a previous study [ 35].

We consider the low response rate (31%) to be the most critical limitation as this poses a risk of selection bias.

The most critical limitation of the aforementioned models is that they are all animal models that develop characteristics of hypertrophic scars.

The most critical limitation of this study is that the results were obtained from a single cohort, even though the ACTS-GC was a large, randomized, phase III trial.

Perhaps the most critical limitation of our approach is the lack of emission and toxic equivalent factors for some substances of interest (which are therefore omitted from the ranking), as well as the accuracy of those factors that are available.

Focal point of this review is to provide a comparative display of qualitative and quantitative methodologies employed for the appraisal of interacting energy and climate policies, underlying their key features while presenting the most critical issues and limitations not addressed so far.

However, there are many diverse problems facing STEM education in the US, one of the most critical is the limitation of current measurement tools and evaluation methodologies.