The feedback model encapsulates the most critical interactions occurring between the wheel/rail structural dynamics, rolling contact mechanics and rail wear.
It is not reasonable, however, to assume that the most critical interactions are only between loci with main effects.
The mechanism of TNFα-induced sensitization was supported by a mathematical model that correctly reproduced the most critical interactions associated with Bid and Bim, the prominent role of XIAP as a caspase-3 buffer, as well as the neutralization function of the Bcl-2-like survival factors.
To further compare how PcTx1 and GxTx-1E interact with helices in ASIC and Kv channels, we alanine-scanned GxTx-1E to identify residues that are most critical for interaction with the Kv2.1 channel.
The M0418 construct demonstrated a reactivity profile in which residues P59, F62, P63 and K65 were most critical for the interaction; I56, G61 and Y66 were of intermediate importance while several others, for example, S57 and E60, were less important.
In addition, this method produced quantitative insight into the epitope residues most critical for the antibody antigen interaction and enabled the relative affinities of each antibody toward alpha toxin variants to be estimated.
The obtained results have allowed us to find the most critical parameters, the main interactions between them and to determine the combination of values that maximizes the average performance and its robustness to noise factors.
Neither mood nor arousal alone but their interaction appears most critical to understanding the emotional enhancement of memory.
Emphasis has also been placed on trying to understand why these hippocampal medial diencephalic interactions supporting memory should be reciprocal, and to determine for which forms of memory these interactions are most critical.
It may be likely that the structure-activity relationship of antifungal compounds could possibly be associated with multiple factors, unlike in bacteria where cell wall interactions are most critical.
