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"All recognize that the age at the first period, which I think is the most critical event, has not changed, which would suggest to me that the tempo of puberty has not changed," said Dr. Edward Reiter, president of the Lawson-Wilkins Pediatric Endocrine Society and a pediatric endocrinologist at Baystate Medical Center Children's Hospital in Massachusetts.
The generation and accumulation of Aβ is the most critical event in the development of AD, suggesting that the clearance of Aβ could provide a valuable strategy for the treatment of AD.
Formation of aposporous initials is the first and most critical event for occurrence of apospory.
The functional loss of E-cadherin is the most critical event linked with EMT.
The development of the ability to invade surrounding tissues is perhaps the most critical event in cancer progression.
The most accurate description of the pathophysiology of gallstone pancreatitis is found in Opie's original report, in which he proposes 'pancreatic outflow obstruction' as the most critical event for disease onset.
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Facility disruptions are among the most critical events that supply chains can experience.
Low-velocity impact is the one of the most critical events to reduce the reliability of composite structures, because it can generate hidden damages such as delamination inside the structures.
"This marked one of the most critical events for Earth's evolution".
As to many of the most critical events in his life, and how he felt about them, I claim no special insight.
As regards the mitochondrial pathway, the most critical events during apoptosis are the release of cytochrome c from mitochondria into cytosol, after development of the mitochondrial transition pore.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com