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What are the most critical developmental time points for producing a later-life effect of an exposure?
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Identification of the most critical windows of developmental vulnerability is paramount to understanding when and under what circumstances a child is at elevated risk for autism.
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Thus, formation of 5hmC promotes neuronal differentiation by modulating the expression of genes most critical in this important developmental transition.
One important aspect of this research will be the identification and functional characterization of genes regulating the developmental stages most critical for determining yield and of genes which aid plant adaptation to a changing environment.
Estrogens are necessary for ovarian differentiation during critical developmental windows in most vertebrates and promote the growth and differentiation of the adult female reproductive system[1].
Summing it up, the results indicate that early developmental window and the neonatal period of time are the most critical for flutamide-induced changes later in life of the boar.
Consistently it has been shown that exposure of the developing mammalian brain to most general anaesthetic drugs causes some degree of neuronal apoptosis and neurodegeneration during critical developmental periods.
These designs typically reconstruct historical exposures corresponding to the pertinent developmental window – the prenatal and early life periods – which are likely to be the most critical windows for effects of toxicant exposures on neurodevelopment [ 4, 5].
The gametocyte-to-ookinete-to-oocyst developmental transition is completed within the first 24 h in the mosquito midgut and is the most critical stage of the entire transmission cycle.
Below, some of the most critical changes.
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