Sentence examples for most critical determinants from inspiring English sources

While density is one of the most critical determinants of penetrance of Wolbachia-induced phenotypes [18] [20], only virion-free Wolbachia were observed to contact the host spermatids [17].

I hypothesize that energy consumption and energy protection are the most critical determinants in evolution, to undergo either negative selection or positive selection, respectively.

However, it is still needed to identify the appropriate cell types, origin, and processing protocols as the most critical determinants to achieve successful outcomes [ 12].

Although the mechanisms are not fully understood, epidemiological and experimental data suggest that exposure to estrogens, through endogenous production and exogenous exposures resulting in an imbalance in the estrogen/progesterone ratio, may be the most critical determinants in disease risk [ 6- 8].

When the more-global picture of upstream and downstream PI3K signaling is taken into account (for example, amplification or mutation of upstream GFRs, mutation of insulin receptor substrates (IRSs), and mutation of NF-κB), this points to the PI3K pathway as being one of the most critical determinants in breast cancer initiation and progression [ 12].

This is unfortunate because spatial variation in birth rate (reproduction) is probably the most critical determinant of geographic range boundaries [2].

In spite of the massive lymphadenopathy and documented defects in activated T-cell apoptosis in Bim-deficient lpr mice, it remains uncertain which cell type is the most critical determinant triggering exacerbated autoimmunity in these mice.

A study conducted in nearly 2000 patients in PCCs in Taiwan found that physician technical competence/skills was the most critical determinant of perceived quality for both overall satisfaction and recommendation, followed by interpersonal skills [ 48].

Although the release of peptide into solution is likely beneficial to hemostasis, its response when in direct physical contact with blood at the site of injury is the most critical determinant to its success.

As IL-4 is a most critical determinant in regulating immune responses by promoting Th2 cell development and inhibiting Th1 cell differentiation, we analyzed the role of single nucleotide polymorphisms (SNPs) in the IL-4 receptor (IL-4R) α-chain, which is critical for binding of IL-4 and for IL-4 signal transduction, in the differentiation of human T cells.

As IL-4 is a most critical determinant in regulating immune responses by promoting Th2 cell development and inhibiting Th1 cell differentiation, we analyzed the role of single nucleotide polymorphisms (SNP) in the IL-4 receptor α-chain, which is critical for binding of IL-4 and for IL-4 signal transduction, in the differentiation of human T cells.