Our phylogenomic analysis of the APC/C, its main adaptors/co-activators and targets supported the hypothesis that most of the corresponding genes were already present in LECA.
Thirdly, a conspicuous set of genes encoding cellulases or glycosylhydrolases is apparent, which has no counterpart in other nematodes but is most similar to corresponding genes in Dictyostelium or other microbes.
Most of the corresponding genes did not display homology to any other known proteins, except for families RSSC-T3E-Hyp5, Hyp6 and Hyp7 having homologues only in Acidovorax spp or Xanthomonas spp, which are both plant pathogenic bacteria.
Most of the corresponding genes were however not placed in the current assembled genome of the lizard and, as for the [LHβ]-containing paralogous gene set and likely because of the same difficulties, not found in the current version of the chicken and turkey genomes.
A germ line mutation in one of these corresponding genes, most often MLH1 or MSH2, is the cause of dMMR in patients with Lynch syndrome, formerly Hereditary Non Polyposis Colorectal Cancer (HNPCC), which comprises 0.8 5% of all CRCs (Mecklin, 1987; Rodriguez-Bigas et al, 1997; Cunningham et al, 2001).
In our study, transcripts with no expression in the uninfected condition, but which are induced upon infection, could be considered the most infection-specific and the corresponding genes potentially interesting ones.
Genomic studies have confirmed that malaria parasites possess most of the panoply of corresponding genes (see Table 1).
Interestingly, those peptides show the N-terminal NatB target sequence (Table 1) indicating that the corresponding genes have most likely alternative translation start codons as indicated by the N-terminal methionine of these peptides.
ADAMTS3 and ADAMTS14 are phylogenetically closer to each other than to ADAMTS2, indicating that their corresponding genes were most probably duplicated through the 1R- and 2R-WGD, with the counterpart of ADAMTS2 being lost after the second vertebrate WGD.
The other five genes (wbmF, wbmG, wbmH, wbmI and wbmK), which encode putative nucleotide sugar epimerases/dehydratases and amidotransferase, are not present in the C. violaceum, N. meningitidis and N. gonorrhoeae genomes, but are most closely related to the corresponding genes for the biosynthesis of the O-antigens in Bordetella parapertussis and Bordetella bronchoseptica [ 53].
