Most T6SS core components correspond to structural elements of the secretion machinery.
Similar improvements over time were also seen in most ACR core components (figure 3).
Evi as a potential 'druggable' target is one of the most 'upstream' core components of the Wnt signalling pathway and is required for the export of Wnts ligands.
Despite the large evolutionary distances that separate the stramenopiles from well-studied organisms such as yeast or Arabidopsis, most of the core components of mitochondrial protein import systems appear to be encoded by the Ectocarpus genome.
Most known PB core components were identified (exceptions include the Ccr4/ Pop2/ Not1 complex and Scd6), and relative to all proteins co-isolated with Dhh1 GFP, the family of decapping proteins Dcp1, Dcp2, Edc3, Pat1, Lsm1-7, and exonuclease Xrn1, were the most abundant PB proteins (highest spectral counts) isolated from cells grown either in −glucose or +glucose media (Table S2).
The data reported here indicate that the JNK pathway in C. floridanus is quite similar to the pathway in D. melanogaster, since most of the core components of the JNK pathway of D. melanogaster have homologs in C. floridanus (Fig. 6).
Fluorescence recovery after photobleaching (FRAP) experiments have been instrumental in classifying most SJ proteins as core components based on their limited mobility after photobleaching and the observation that upon loss of function other SJ proteins diffuse rapidly into the bleached region due to impaired complex formation (Laval et al., 2008; Oshima and Fehon, 2011).
Several components of the CIA machinery have previously been identified and most of them appear to be core components that are needed to assemble many different proteins in cells.
Based on the rescaled coefficients, respondents considered instrumental research use to be most extensive if research influenced the core components of the decision or course of action (as opposed to providing additional or vague details) and policymakers could identify the specific research that influenced these decisions.
Once again some core components are strongly conserved most notably a G-protein (Rho1), protein kinase C (Pkc1), and a MAP kinase (Slt2).
