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Mocarelli and colleagues (15) first reported a dramatically reduced sex ratio of 0.54 among 74 offspring born 9 months following the exposure in 1977 1984 to parents who lived in the most contaminated zone.
Statistically significant differences (p < 0.05) were observed between the geometric mean tooth lead level of 6.44 micrograms Pb/g (n = 13; 95% CI = 3.95; 10.50) in the most contaminated zone and 1.43 micrograms Pb/g (n = 35; 95% CI = 1.11; 1.84) in zones farther away from the point source.
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There would most likely be no observable increase in cancer rates for the general population in Fukushima Prefecture outside the most contaminated zones, in the rest of Japan and the world, the report said.
Nevertheless, elevated serum TCDD levels measured in Seveso women who lived in the two most contaminated zones were associated with increased breast cancer risk in a first analysis conducted in 2002 [ 9].
More than two decades after the Seveso accident, Baccarelli and colleagues (17) found a normal sex ratio (SR = 1.06) in 481 offspring of women who lived in the most contaminated zones before 1980.
In 1996, we initiated the Seveso Women's Health Study, a retrospective cohort study of women who resided in the most contaminated areas, zones A and B. We examined the relation of pregnancy outcome in 510 women (888 total pregnancies) to maternal TCDD levels measured in serum collected shortly after the explosion.
Eligible women were newborn to 40 years of age in 1976, resided in zones A or B (the most highly contaminated zones), and had a blood sample collected soon after the explosion that was of adequate volume for analysis of TCDD.
In the sale zone, the most contaminated sites were the tables for carcass display (24%) and scales (21%).
In the slaughter zone, the most contaminated sites were the poultry-processing tables (21%), baskets holding poultry meat (20%), and chopping boards (20%).
The area where the toxic cloud released by a chemical factory deposited was subdivided into three zones based on measurements of TCDD soil levels [ 13]: Zone A (the most heavily contaminated), zone B (medium exposure) and zone R (low exposure); a surrounding non-contaminated territory including 11 municipalities was adopted as reference (figure 1).
A thin (3 ft thick) section of the perched-water zone was the most contaminated; total aromatic hydrocarbons were as high as 19.4 mg/l.
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