The results are most consistent with a regulatory locus within a 32 kb region of the CFH gene, with a major effect on plasma CFH concentration and AMD susceptibility.
Although all studies lacked rigorous replication, we identified four classes of genes harboring loci that showed most consistent evidence of gene-lifestyle interactions in diabetogenic traits: the β2 adrenergic receptor (ADRB2), uncoupling proteins (UCP) 1-3, lipid-related LIPC (LPL,, LPL, FABP2, APOC3, and APOE), and the peroxisome proliferator-activated receptor-γ (PPARG).
Variation at the apolipoprotein E (APOE) gene locus is the most consistent nondeterministic genetic risk factor for late-onset Alzheimer's dementia.
Among these loci, the locus on chromosome 3q21.1-q26.2 was the most consistent finding providing positive results in both parametric and nonparametric analyses Heterogeneity LOD score (HLOD) = 1.90, alpha = 0.45, Non-Parametric LOD score (NPL) = 2.1).
Our in vivo MIRU mutation rate, 2.70 × 10-03 per locus, per year, is most consistent with the highest publocusd estimates.
Following this step, several filters were applied to identify the loci with the highest and most consistent genotyping.
Additionally, the MHC locus on chromosome 6p was the most consistent finding from GWA studies [ 1- 3].
Consistency, it seems, is Keys's most consistent trait.
Cis-regulation caused by mutations in the promoter sequence upstream from the CHS transcriptional start site is most consistent with the solitary nature of the CHS expression difference among the eight ABP-related loci examined.
For example, analyzing the candidate full-length models (in sets Fall and F), as well as the conformations most consistent with experimental data (in set Fout100), revealed that the domains occupy relatively well-defined loci.
