In 2006, when the IARC classified lead as a probable carcinogen, the epidemiological evidence was the most consistent for stomach cancer, with elevated kidney and lung cancer risks observed in some but not all studies (IARC 2006).
Evidence for carcinogenicity in workers exposed to inorganic lead is most consistent for stomach cancer (rate ratio, 1.3 1.5), with lung, kidney, and brain cancer showing elevation in some but not all studies (IARC 2006c).
"Right now, the lesions are most consistent with a cancer, and that is unfortunately a disease we associated with age," said Haulena, "So we're looking at a great life for a great whale who had almost nothing wrong with her".
Alternation in cellular metabolism to anaerobic state is most consistent hallmark of cancer [ 15].
The strongest and most consistent associations with cancer risk in our study were with menopausal status and age at menopause.
Cancers in laboratory animals and humans do not always occur in analogous or the same target/system; for example, rodent Zymbal gland tumors were the first and most consistent benzene-induced cancer response observed, but humans do not possess Zymbal glands.
Our next step in the analysis was to compare metabolite levels in the cancers based on ER status (ER + versus ER-), the most consistent division in breast cancer from both a biologic and therapeutic perspective.
Aberrant methylation of the sFRP1 promoter is one of the most consistent alterations in human cancer.
While the strongest and most consistent division in breast cancer is between the basal and luminal types and systematic differences strongly suggest a different cell of origin for these two dominant categories [ 1- 5] additional molecular or mechanistic heterogeneity can be identified within classes.
Hypermethylated tumor suppressor genes represent one of the most consistent hallmarks of human cancers [ 12, 18].
