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The most common target site coincides with the evolutionary most conserved part of Alu.
Since "TGA" from position 2 to position 5 is the most conserved part of the new motif, we focused the point mutations to these three positions.
These two panels reveal that the inner core of the transporters is the most conserved part and this is particularly true for the transmembrane domain.
The presence of cap structure as well as poly(A) tails in a portion of the transcripts indicate RNA polymerase II dependent transcription and a putative polymerase II promoter site overlaps the most conserved part of the PRAT sequence.
However, the most conserved part of human 5F7 is marked by monomethylation on lysine 4 of histone H3 (H3K4me1) in embryonic stem cells (H1-hESC), a modification associated with enhancers [37], [38].
The putative promoter element is detected with a high score of 0.95 in 52% of PRAT DNA monomers as well as in 80% of PRAT RNA monomers, between positions 40 89 nt of reverse strand (Fig. 3c), overlapping exactly with the most conserved part of the PRAT sequence, as previously revealed by sequence comparison [18].
Similar(26)
It has the potential considerable advantage of focusing the T cell responses on the most conserved parts of the virus and thus overcoming the usual patterns of immunodominance, while making it difficult for the virus to escape without a likely significant cost to its fitness.
However, the sequences used in this study correspond to coding sequences from which we extrapolated their most conserved parts (cores) to perform alignments.
Furthermore, microarray and whole genome PCR scanning analyses have shown that LEE GEI constitutes one of the most conserved parts of different EHEC strains.
The T4SS transfer module was found to be one of the most conserved parts of the ICE Hin1056 subfamily of GEIs (Juhas et al., 2007b).
For the miRNA genes in the human chromosome 19 cluster, the encoded seed sequence was found to be complementary to the most conserved parts of Alu RNA [ 29].
More suggestions(15)
most difficult part
most conserved state
most conserved glycosylation
most conserved gene
most important part
most conserved target
most unfair part
most conserved region
most hilarious part
most magical part
most conserved cluster
most conserved group
most conserved plant
most conserved protein
most conserved locus
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